MILED Trial Info Video from The LAM Foundation on Vimeo.

 

The MILED Trial is a new research study designed to answer the question of whether we should be starting sirolimus at low doses earlier in the course of LAM, before symptoms develop and while lung function is still normal, similar to the manner in which we treat diabetes and high blood pressure early to prevent future heart and kidney complications.

You may be eligible if you:

  • Are an adult woman with LAM
  • Have an FEV1 greater than 70% predicted
  • Are not currently taking sirolimus

During the study, participants will:

  • Attend 8 study visits over 2 years (about one visit every 4 months)
  • Complete blood tests, a physical exam, and pulmonary function tests at visits
  • Answer questions about breathing, fatigue and quality of life
  • Take one capsule every day (1 mg sirolimus or a sugar pill) throughout the study
  • Record their pill taking and any side effects in an electronic diary

Participants will receive:

  • Physical exams, pulmonary function tests, a chest x-ray, and laboratory tests free of charge
  • Study drug (either 1 mg sirolimus or placebo) throughout the study
  • Reimbursement for travel expenses to attend each study visit

 

You can enroll in the MILED Trial and still participate in the LAM protocol at the NIH.

To get more information or to see if you may be eligible, please contact Susan McMahan, BSN, RN, CPN, CCRP, Project Manager at the University of Cincinnati, the clinical coordinating center for the study, or Frank McCormack, MD, Principal Investigator for MILED.We can answer your questions, provide additional information, and refer you to the closest MILED study site.  Susan’s contact information is: susan.mcmahan@uc.edu  phone: 513-558-4376.

Sites that are welcoming new participants are in Atlanta, Boston, Chicago, Cincinnati, Denver, Philadelphia, Seattle and Palo Alto. Coming soon: sites in New York City and Los Angeles!

Please see the LAM Foundation’s website or clinicaltrials.gov for more details about the MILED Trial.

 

MILED Trial Sites and Contact Informationplus

 

 

Site

Principal Investigator (PI)

Research Staff

CRC Contact Information

Emory University

Srihari Veeraraghavan,MD

 

Tracy Halaby

tracy.halaby@emory.edu

Brigham and Women’s–Harvard

 

Elizabeth Henske, MD

Shefali Bagwe

sbagwe@bwh.harvard.edu

Loyola University

 

Dan Dilling, MD

Josie Corral

jcorral@luc.edu

National Jewish Health

Gregory Downey, MD

Jami Henriksen

henriksenj@NJHealth.org

 

Stanford University Medical Center

 

Stephen Ruoss, MD

Susan Jacobs

 

ssjpulm@stanford.edu

Swedish Minor and James

 

George Pappas, MD, MPH

Julie Wallick

Julie.Wallick@swedish.org

University of Cincinnati

 

Frank McCormack, MD

Nishant Gupta, MD

Susan McMahan

susan.mcmahan@uc.edu

 

University of Pennsylvania

 

Maryl Kreider, MD

Sara Deitrick

sara.deitrick@uphs.upenn.edu