LAM_Journeys_Blog-01-01

Search for an Article

 Search

To search by keyword(s), simply type the words in the search box and click Search.

To search for a specific phrase, enter the phrase within quotation marks and click Search.

To search for predetermined topics/tags or by type of resource, scroll down until you see the category and tags sections on the left navigation bar of this page. Then click on the category or topic of interest to reveal the corresponding videos.

Topic

Featured Article

Zooming into What Matters Thumbnail 1.png

Zooming-In on What Matters: Education. Connection. Hope.

Posted on April 16, 2021   |   

March 2020. LAMposium as we know it is cancelled. May 2020. LAMposium in Your Living Room goes viral. Whoops, that is, virtual.

Last spring, when it became clear to us that we would not be gathering as a LAM community in Cincinnati, we at the Foundation quickly shifted our focus to designing virtual experiences that would capture the key elements of our beloved LAMposium. It is this vision that frames our virtual educational series, Read More

Topics: LAMposium in Your Living Room        Categories: Educational Resources

Recent Articles

Articles for tag Single Cell Analysis

scRNAseq images.jpg

Single Cell RNA Sequencing Allows Comprehensive Study of the Genetic Programs of All Cell Types in a Diseased Human Lung

Posted on July 23, 2018   |   

Studying LAM biological behavior in the laboratory is difficult because the model-based approaches that have been so vital to progress in other diseases have simply not been very good in LAM. There are many reasons for the inadequacy of LAM cell models, including that we don’t know the origin of the LAM cell, and that LAM cells grow slowly, change their signature functions with time in a dish, are often outcompeted by other cells in culture, and do not survive well through multiple passages. Immortalizing LAM cells with viruses can keep them alive but alters them in unpredictable and inauthentic ways. LAM animal models are also problematic; there is no known naturally occurring model of LAM other than in humans, and because we don’t know where LAM starts in the body, we don’t know what cell to target with our genetic manipulations.

Read More

Topics: Single Cell Analysis        Categories: Educational Resources