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Featured Article

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Finding Hope Through LAM Community Engagement

Posted on May 14, 2021   |   

I was diagnosed with LAM and probable Tuberous Sclerosis Complex (TSC) in 2019 at 26 years old, when I was working three jobs and attending graduate school in Colorado. As an active twenty-something still trying to figure out my life, the stress of understanding what this diagnosis meant for my future weighed heavily on me.

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Topics: Community Engagement diagnosis        Categories: Patient Profiles

Recent Articles

Author: Anne McKenna - Community Manager

Q&A: The MILED Trial

Posted on September 25, 2018   |   

Published 9/25/2018

The MILED Trial is a currently enrolling study led by Dr. Frank McCormack, Scientific Director of The LAM Foundation. The trial seeks to answer an important clinical question about early treatment of LAM. That question is: “Does early treatment of mild LAM symptoms with low dose sirolimus stop progression of disease and cyst formation in the lungs?” The answer to this question will benefit patients with LAM all around the world.

Here, we answer your own questions about the MILED Trial. 

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Topics: clinical trial Dr. Frank McCormack MILED Sirolimus        Categories: Educational Resources
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We Need Your Help to Fund LAM Research

Posted on August 03, 2018   |   

"The LAM community should be incredibly proud of the Foundation’s continuing role in fast-tracking the best LAM research” – Elizabeth Henske, MD

We need your help to fund LAM research. The LAM Foundation is the global leader in the fight against lymphangioleiomyomatosis (LAM). We are dedicated to finding safe and effective treatments, and ultimately a cure, for women living with LAM. By donating today, you can help give “A Breath of Hope” to women with LAM across the globe. 100% of your gift will go directly to LAM research.

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Topics: LAM Research        Categories: News
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Single Cell RNA Sequencing Allows Comprehensive Study of the Genetic Programs of All Cell Types in a Diseased Human Lung

Posted on July 23, 2018   |   

Studying LAM biological behavior in the laboratory is difficult because the model-based approaches that have been so vital to progress in other diseases have simply not been very good in LAM. There are many reasons for the inadequacy of LAM cell models, including that we don’t know the origin of the LAM cell, and that LAM cells grow slowly, change their signature functions with time in a dish, are often outcompeted by other cells in culture, and do not survive well through multiple passages. Immortalizing LAM cells with viruses can keep them alive but alters them in unpredictable and inauthentic ways. LAM animal models are also problematic; there is no known naturally occurring model of LAM other than in humans, and because we don’t know where LAM starts in the body, we don’t know what cell to target with our genetic manipulations.

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Topics: Single Cell Analysis        Categories: Educational Resources
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Why We Ride: Million Dollar Bike Ride

Posted on March 29, 2018   |   

Joe & Mary Van Brackel share a bit about their experience participating in the Million Dollar Bike Ride sponsored by the Penn Medicine Orphan Disease Center.

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Categories: Events
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HOPE 2.0

Posted on March 09, 2018   |   

CEO, Sue Sherman talks about the significance of the recent Patient Benefit Conference and how The LAM Foundation is embarking on HOPE 2.0.  

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Topics: Patient Benefit Conference        Categories: Events
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